![]() ![]() Cytokine signature associated with disease severity in chronic fatigue syndrome patients. Montoya JG, Holmes TH, Anderson JN, et al. Myalgic encephalomyelitis/chronic fatigue syndrome - Evidence for an autoimmune disease. Fatigue, sleep, and autoimmune and related disorders. Sleep duration and affective reactivity to stressors and positive events in daily life. Sin NL, Wen JH, Klaiber P, Buxton OM, Almeida DM. Are you getting too much exercise?Īmerican Psychological Association. National Library of Medicine: MedlinePlus. Increased physical activity improves sleep and mood outcomes in inactive people with insomnia: A randomized controlled trial. Sedentary behaviour and 12 sleep problem indicators among middle-aged and elderly adults in South Africa. National Institutes of Health, National Institute on Aging. Could a vitamin or mineral deficiency be behind your fatigue? Stress, non-restorative sleep, and physical inactivity as risk factors for chronic pain in young adults: A cohort study. Some may cause insomnia, including prednisolone, methylprednisolone, dexamethasone Steroids: Used for inflammation, allergies, skin diseases, certain cancers, and after organ transplants.Statins: Especially fat-soluble drugs including Lipitor (atorvastatin), Mevacor (lovastatin), Vytorin (ezetimibe/simvastatin), Zocor (simvastatin).Sedatives: Non-benzodiazepine sedative/hypnotics such as Ambien (zolpidem), Sonata (zaleplon), Lunesta (eszopiclone).Muscle relaxants: Including Soma (carisoprodol), Lorzone (chlorzoxazone), Flexeril (cyclobenzaprine).Blood pressure drugs: Diuretics, ARBs, calcium channel blockers, beta-blockers including Lasix (furosemide), Avapro (irbesartan), Calan (verapamil HCL), Toprol-XL (metoprolol succinate).Benzodiazepines: Tranquilizers and sedatives such as Librium (chlordiazepoxide), Valium (diazepam).Antipsychotics: Drugs for schizophrenia, psychosis in bipolar disorder, depression, and Alzheimer's disease including Abilify (aripiprazole), Risperdal (risperidone), Seroquel (quetiapine).Antihistamines: Allergy medications including Zyrtec (cetirizine), Claritin (loratadine), Benadryl (diphenhydramine).Antiemetics: Drugs for nausea, vomiting, and motion sickness such as Dramamine (dimenhydrinate), Anzemet (dolasteron), Zyprexa (olanzapine), Reglan (metoclopramide).Antidepressants: Tricyclics and SSRIs/SNRIs including Elavil (amitriptyline), Prozac (fluoxetine), Cymbalta (duloxetine).Anticonvulsants: Seizure prevention drugs such as Neurontin (gabapentin) and Lyrica (pregabalin).Analgesics: Painkillers including opioids such as Vicodin (hydrocodone-acetaminophen), Ox圜ontin (oxycodone).This can lead to increased accidents and possibly a higher risk of some forms of cancer. Shift-work sleep disorder: Poor sleep is caused by working at night and sleeping during the day.The sleep cycle is typically a little longer than average and thus becomes more out of sync every day. Non-entrained (non-24) disorder: This usually occurs in visually impaired people.To adjust, it may take one day for every time zone you crossed. Jet lag: A temporary rhythm disorder associated with travel across several time zones.Sleep is fragmented, with short spells scattered throughout the day. Irregular sleep-wake rhythm: This occurs when the circadian rhythm becomes completely disconnected from the natural day-night cycle.Delayed sleep phase syndrome: Similar to insomnia, this causes difficulty falling asleep and makes it extremely hard to wake up.Advanced sleep phase syndrome: The distinguishing feature is falling asleep and waking up earlier than you want, usually by about three hours.In about 10 percent of cases, narcolepsy runs in families. ![]() Less often, the cause of narcolepsy is an injury that damages the brain. Their immune system mistakenly turns against their body and attacks the brain cells that produce hypocretin. Some people experience hallucinations and sleep paralysis when they’re falling asleep or waking up.Ĭertain people with autoimmune disorders are more likely to get narcolepsy with cataplexy. The lack of hypocretin makes it hard for someone to stay awake during the day, blurring the line between wakefulness and sleep. That loss of muscle tone causes you to lose control over your body when you’re awake. It’s the same loss of muscle tone that naturally happens during rapid eye movement (REM) sleep. The loss of muscle tone, cataplexy, happens because sleep and wakefulness overlap in narcolepsy. When it’s in short supply, your brain has trouble regulating your sleep-wake cycles. This chemical, which is produced in a brain region called the hypothalamus, controls sleep and wakefulness. Low levels of the chemical hypocretin cause narcolepsy with cataplexy. Narcolepsy affects signals in your brain that are supposed to keep you awake. ![]()
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